Elucidating an uncommon disease inflammatory breast cancer

Elucidating an uncommon disease inflammatory breast cancer

We are entering a very exciting time in inflammatory breast cancer and in aggressive cancers in general where we are uncovering brand new targets, said Sofia Merajver, M. D., codirector of the breast cancer research program at the University of Michigan, Ann Arbor.They seem to be hugely informative about the behavior of these cells.Rho C plays a role in signal transduction from growth factor receptors on the cell surface to the cytoplasm and is involved in the reorganization of the cytoskeleton; it is instrumental in a cells motility and its ability to metastasize.

Schneiders work is important, Merajver said, because it not only identified the e IF4G1 gene, it also explained a possible role of the gene in the progression of IBC.Researchers knew that IBCs tended to have low expression of estrogen and progesterone receptors, but this was hardly a characteristic feature that could be used to identify the disease or explain its devastating effects.What we set out to understand, Merajver said, is why this tumor progresses so fast and seems metastatic from its inception.But in IBC, Kleer showed that E-cadherin may persist and play a key role in maintaining the structure of the tumor emboli, allowing them to metastasize as entire structures.And now, researchers at the New York University Cancer Institute have identified a new gene, called e IF4G1, that may be another possible marker of IBC. D., an associate director at the Institute, and Deborah Silvera, Ph.

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